Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593999 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1â3)Glc and Glc(α1â3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1â3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1â6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.
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Authors
Ian Cumpstey, Clinton Ramstadius, K. Eszter Borbas, Dominic S. Alonzi, Terry D. Butters,