| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594003 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of pantolactam based compounds were identified as potent antagonists for the androgen receptor (AR). Those that possessed properties suitable for topical delivery were evaluated in the validated Hamster Ear Model. Several compounds were found to be efficacious in reducing wax esters, a major component of sebum, initiating further preclinical work on these compounds.
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Authors
Karen E. Sexton, Stephen Barrett, Katy Bridgwood, Matthew Carroll, Danielle Dettling, Daniel Du, Stephen Fakhoury, Victor Fedij, Lain-Yen Hu, Catherine Kostlan, David Pocalyko, Neil Raheja, Yvonne Smith, Veerabahu Shanmugasundaram, Kimberly Wade,