| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594023 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul Eastwood, Jacob González, Elena Gómez, Francisco Caturla, Cristina Balagué, Adelina Orellana, MarÃa DomÃnguez,