Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594063 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
This paper reports the synthesis of methoxy- and bromo-indirubins, and their antiproliferative activities in human neuroblastoma. Among 20 compounds, 5â²-methoxyindirubin induced cell death in human neuroblastoma cells (IMR-32, SK-N-SH and NB-39) without inhibiting normal cells (NHDF and HUVEC). Typical morphologic features of apoptosis were observed in 5â²-methoxyindirubin-treated cells by Hoechst 33342 staining. Additional studies by flow cytometry support apoptosis induction. These data suggest that 5â²-methoxyindirubin might be an effective drug for treatment of neuroblastoma.
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Authors
Hiroaki Saito, Keiichi Tabata, Satoshi Hanada, Yuko Kanda, Takashi Suzuki, Shinichi Miyairi,