| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594081 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities. The best inhibitors provided IC50 values in the micromolar range, with a best value of 41 μM.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mounir Andaloussi, Martin Lindh, Christofer Björkelid, Surisetti Suresh, Anna Wieckowska, Harini Iyer, Anders Karlén, Mats Larhed,