Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594093 | Bioorganic & Medicinal Chemistry Letters | 2012 | 34 Pages |
Abstract
SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yithachu Thur, Amit Bhalerao, Zaki Munshi, Nisha Pansare, Klaus Mann, Guido Hanauer, Hans-Peter Kley, Sandra Nappe, Cornelia Weiss-Haljiti, Claude Ostermann, Christof Zitt, Michaela Schaefer, Dibyendu Mondal, Afsar Ali Siddiki, Velavan Armugam,