| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594164 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site mGlu5 PAM chemotype.
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Authors
Alice L. Rodriguez, Ya Zhou, Richard Williams, C. David Weaver, Paige N. Vinson, Eric S. Dawson, Thomas Steckler, Hilde Lavreysen, Claire Mackie, José M. Bartolomé, Gregor J. Macdonald, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones,