Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594181 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The chlorambucil l-histidine conjugate was synthesized and radiolabeled with [99mTc(CO)3]+ core to form the 99mTc(CO)3(His-CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of 99mTc(CO)3(His-CB) as a tumor imaging agent.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianjun Wang, Jing Yang, Xiaojiang Duan, Yanhua Zhang, Wenjiang Yang, Yu Liu,