| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594183 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2-carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Variam Ullas Jeankumar, Manoj Chandran, Ganesh Samala, Mallika Alvala, Pulla Venkat Koushik, Perumal Yogeeswari, Elena G. Salina, Dharmarajan Sriram,