| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594187 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives were designed and synthesized as 5-HT6 receptor (5-HT6R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities and activity in animal models of cognition.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ramakrishna V.S. Nirogi, Rajeshkumar Badange, Ramasastri Kambhampati, Anil Chindhe, Amol D. Deshpande, Vinaykumar Tiriveedhi, Vishwottam Kandikere, Nageswararao Muddana, Renny Abraham, Mukkanti Khagga,