| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594189 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of di-indolinone derivatives was designed and synthesized to optimize our lead compounds basing on molecular docking study as PTP1B inhibitors. Successive enzymatic assay identified the synthetic di-indolinone as novel PTP1B inhibitors with low micromole-ranged inhibitory activity and at least several-fold selectivity over other tested homologous PTPs.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hou-ling Dai, Li-xin Gao, Ying Yang, Jing-ya Li, Jia-gao Cheng, Jia Li, Ren Wen, Yan-qing Peng, Jian-bin Zheng,