| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594194 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of 3-deazauridines (3-DU) analogues were synthesized and evaluated in vitro for their antiherpetic activity against HSV-1 on Vero cell lines by cell viability. A first campaign of tests suggested that C3-arylated-3-DU derivatives could constitute a novel family of antiherpetic agents. A second campaign of biological evaluations led to the discovery of two potent anti-HSV-1 agents with comparable activity than acyclovir.
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Authors
Julien Lalut, Ludovic Tripoteau, Christel Marty, Hugo Bares, Nathalie Bourgougnon, François-Xavier Felpin,