| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594250 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Potent bRAF inhibitors containing 3-methoxy-2-aminopyridine moiety were shown to be representative examples of an electron rich heteroaryl associated with time-dependent drug-drug interactions and mutagenicity. These risks may be reduced by either reducing electron density or preventing the formation of the mutagenic metabolite.
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Authors
Cynthia Palmer, Mason Pairish, Susan Kephart, Djamal Bouzida, Jingrong Cui, Judith Deal, Liming Dong, Danlin Gu, Angelica Linton, Indrawan McAlpine, Shinji Yamazaki, Evan Smith, Annette John-Baptiste, Shubha Bagrodia, Robert Kania, Chuangxing Guo,