| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594261 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
The inhibition of FLT-3 activity is an interesting target for the treatment of acute myeloid leukemia (AML). The serendipitous identification of FLT-3 inhibitors from a CK1/γ-secretase programme provided compounds with dual inhibitory activity. We analyzed the structure-activity relationship of these inhibitors and derivatized them to arrive at compounds with reduced impact on γ-secretase activity and enhanced FLT-3 inhibition.
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Authors
Ghislaine Marlyse Okala Amombo, Thomas Kramer, Fabio Lo Monte, Stefan Göring, Matthias Fach, Steven Smith, Stephanie Kolb, Robert Schubenel, Karlheinz Baumann, Boris Schmidt,