| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594277 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Amido-1,3,4-thiadiazoles were identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype-1 agonists. Starting from a micromolar HTS compound we developed a robust structural-activity relationship, to get to a lead that demonstrated good selectivity and excellent in vivo potency in rat models.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nuria Aguilar, Marta Mir, Pedro M. Grima, Manel López, Victor Segarra, Laia Esteban, Imma Moreno, Nuria Godessart, Gema Tarrasón, Teresa Domenech, Dolors Vilella, Clara Armengol, Mònica Córdoba, Mar Sabaté, Daniel Casals, Maria DomÃnguez,