Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594280 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and pharmacodynamic profiles in rat.
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Authors
Yutaka Mori, Yasuyuki Ogawa, Akiyoshi Mochizuki, Yuji Nakamura, Chie Sugita, Shojiro Miyazaki, Kazuhiko Tamaki, Yumi Matsui, Mizuki Takahashi, Takahiro Nagayama, Yoko Nagai, Shin-ichi Inoue, Takahide Nishi,