| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594280 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and pharmacodynamic profiles in rat.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors](/preview/png/10594280.png "First Page Preview: Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors")
Authors
Yutaka Mori, Yasuyuki Ogawa, Akiyoshi Mochizuki, Yuji Nakamura, Chie Sugita, Shojiro Miyazaki, Kazuhiko Tamaki, Yumi Matsui, Mizuki Takahashi, Takahiro Nagayama, Yoko Nagai, Shin-ichi Inoue, Takahide Nishi,