| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594310 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The water-solubility of the highly potent V-ATPase inhibitors archazolid A and the glucosylated derivative archazolid C was studied in the presence of a wide range of cosolvents, revealing very low solubilites. The first water-soluble analogue was then designed, synthesized, and evaluated for V-ATPase inhibitory activity in vitro.
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Authors
Elke Persch, Teodora Basile, Svenja Bockelmann, Markus Huss, Helmut Wieczorek, Teresa Carlomagno, Dirk Menche,