| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594341 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator activated receptor (PPAR) α/γ dual agonists are described. Compound 22e showed a highly potent dual agonist activity, together with a great glucose lowering effect without body weight gain in vivo model.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoshihiro Shibata, Katsuji Kagechika, Mitsuhiro Yamaguchi, Hideo Kubo, Hiroyuki Usui,