Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594357 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.
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Authors
Bo Wang, Yang Liu, Yanshi Wang, Xin Liu, Mao-Sheng Cheng,