| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594361 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Analogues of 5,6-dihydroxypyrimidine (1a-1l, 2a-2c, 3a-3c) were synthesized and evaluated for their anti-HIV activity in vitro. Among all of the analogs, several compounds exhibited significant anti-HIV activity, especially 1b and 1e, which showed the most potent anti-HIV activity with EC50 values of 0.14 and 0.15 μM, and TI (therapeutic index) values of >300 and >900, respectively.
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Authors
Di-Liang Guo, Xing-Jie Zhang, Rui-Rui Wang, Yu Zhou, Zeng Li, Jin-Yi Xu, Kai-Xian Chen, Yong-Tang Zheng, Hong Liu,