| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594377 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.
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Authors
Adam HuczyÅski, Jan Janczak, MichaÅ Antoszczak, Joanna Wietrzyk, Ewa Maj, Bogumil Brzezinski,