| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594391 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains.
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Authors
Muthusamy Venkatraj, Kevin K. Ariën, Jan Heeres, Jurgen Joossens, Jonas Messagie, Johan Michiels, Pieter Van der Veken, Guido Vanham, Paul J. Lewi, Koen Augustyns,