Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594406 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of macrocyclic compounds containing 2-substituted-quinoline moieties have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155K mutant activity while maintaining the high rat liver exposure. Cyclization of the 2-substituted quinoline substituent led to a series of tricyclic P2 compounds which also display superb gt3a potency.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael T. Rudd, John A. McCauley, Joseph J. Romano, John W. Butcher, Kimberly Bush, Charles J. McIntyre, Kevin T. Nguyen, Kevin F. Gilbert, Terry A. Lyle, M. Katharine Holloway, Bang-Lin Wan, Joseph P. Vacca, Vincenzo Summa, Steven Harper,