Article ID Journal Published Year Pages File Type
10594406 Bioorganic & Medicinal Chemistry Letters 2012 6 Pages PDF
Abstract
A series of macrocyclic compounds containing 2-substituted-quinoline moieties have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155K mutant activity while maintaining the high rat liver exposure. Cyclization of the 2-substituted quinoline substituent led to a series of tricyclic P2 compounds which also display superb gt3a potency.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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