| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594456 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
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Authors
Theresa A. Lansdell, Sandra O'Reilly, Tracey Woolliscroft, Lauren M. Azevedo, Daljinder K. Kahlon, Stacy Hovde, J. Justin McCormick, R. William Henry, Joseph A. Cornicelli, Jetze J. Tepe,