Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594465 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the outer membrane of Gram-negative bacteria. SAR evaluation of compounds in this series revealed analogs with potent antibacterial activity against challenging Gram-negative species such as Pseudomonas aeruginosa and Klebsiella pneumoniae.
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Authors
Laura A. McAllister, Justin I. Montgomery, Joseph A. Abramite, Usa Reilly, Matthew F. Brown, Jinshan M. Chen, Rose A. Barham, Ye Che, Seung Won Chung, Carol A. Menard, Mark Mitton-Fry, Lisa M. Mullins, Mark C. Noe, John P. O'Donnell, Robert M. III,