Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594525 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity.
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Authors
Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara, Fumi Nagatsugi,