| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594535 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.
Related Topics
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![N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists](/preview/png/10594535.png "First Page Preview: N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists")
Authors
Ramakrishna V.S. Nirogi, Jagadishu Babu Konda, Ramasastry Kambhampati, Anil Shinde, Thrinath Reddy Bandyala, Parandhama Gudla, Kiran Kumar Kandukuri, Pradeep Jayarajan, Vishwottam Kandikere, P.K. Dubey,