| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594538 | Bioorganic & Medicinal Chemistry Letters | 2012 | 8 Pages |
Abstract
Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.
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Authors
M. Raymond V. Finlay, Roger J. Griffin,