| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594556 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Recently, cysteine residue incorporation increased liposome-mediated transfection compared to unmodified peptide. Therefore, we designed novel modified SV40 NLS peptides, homodimeric (NLS-CTHD, NLS-NTHD) and closed structure (cyclic NLS), simply using disulfide bond between cysteines to develop more efficient and safe non-viral gene delivery system. The simple mix of NLS-CTHD among these novel transfection enhancing peptides with DNA increased the gene transfer potency of cationic liposomes more efficiently with no additional cytotoxicity.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bieong-Kil Kim, Hyungu Kang, Kyung-Oh Doh, Seong-Hye Lee, Jong-Won Park, Su-Jin Lee, Tae-Jin Lee,