| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594566 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.
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Authors
Ian Bruce, Mohammed Akhlaq, Graham C. Bloomfield, Emma Budd, Brian Cox, Bernard Cuenoud, Peter Finan, Peter Gedeck, Julia Hatto, Judy F. Hayler, Denise Head, Thomas Keller, Louise Kirman, Catherine Leblanc, Darren Le Grand, Clive McCarthy,