Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594599 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The synthesis, molecular modeling and biological evaluation of substituted deoxybenzoins and optimized dihydrostilbenes are reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered. Dihydrostilbene 7 is a particularly potent inhibitor (IC50 = 8.44 μM, more potent than kojic acid).
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Argyro Vontzalidou, Grigoris Zoidis, Eliza Chaita, Maria Makropoulou, Nektarios Aligiannis, George Lambrinidis, Emmanuel Mikros, Alexios-Leandros Skaltsounis,