| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594607 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A new fluorogenic substrate 1, which enables the fast and quantitative analysis of alkaline phosphatase activity, has been developed. Selective enzymatic hydrolysis of 1 instantly generated fluorescent compound 2 in aqueous media, which undergo an excited-state intramolecular proton transfer process, resulting in a remarkable fluorescence turn-on signal with an unusually large Stokes shift.
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Authors
Jihye Park, Aasif Helal, Hong-Seok Kim, Youngmi Kim,