| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594631 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model.
Related Topics
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Authors
Neil S. Cutshall, Rene Onrust, Alex Rohde, Sasha Gragerov, Lauren Hamilton, Kevin Harbol, Hui-Rong Shen, Shawn McKee, Charles Zuta, Galina Gragerova, Vince Florio, Thomas N. Wheeler, Jennifer L. Gage,