| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594664 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The serum and glucocorticoid regulated kinase-1 (SGK1) is part of the serine/threonine kinase family and has therapeutic potential in several neurodegenerative diseases such as ischemic stroke and Parkinson's disease. Here we use structure-based virtual screening to identify a novel ligand which inhibits SGK1 activity. The data presented here can be used for future scaffold hopping and possible drug development efforts.
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Authors
Werner J. Geldenhuys, Phani K. Talasila, Prabodh Sadana,