| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594696 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide derivatives with activities against resistant pathogens is urgently needed. A series of novel 6-O-(heteroaryl-isoxazolyl)propynyl 2-fluoro ketolides has been synthesized from erythromycin A. These compounds have shown very promising in vitro and in vivo antibacterial activities against key respiratory pathogens including erythromycin-susceptible/resistant strains.
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Authors
Tomohiro Sugimoto, Yoichi Shimazaki, Akira Manaka, Tetsuya Tanikawa, Keiko Suzuki, Kayoko Nanaumi, Yoshie Kaneda, Yukiko Yamasaki, Hiroyuki Sugiyama,