| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594712 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Elaboration of our previously disclosed spiropiperidine template led to the development of a series of novel CCR5 antagonists as represented by analog 3. Synthetic routes, results of SAR exploration and preliminary lead characterization are described.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis, SAR and evaluation of [1,4â²]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists](/preview/png/10594712.png "First Page Preview: Synthesis, SAR and evaluation of [1,4â²]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists")
Authors
David M. Rotstein, Stephen D. Gabriel, Nicole Manser, Lubov Filonova, Fernando Padilla, Surya Sankuratri, Changhua Ji, Andre deRosier, Marianna Dioszegi, Gabrielle Heilek, Andreas Jekle, Paul Weller, Pamela Berry,