| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594727 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
CRTh2 (DP2) is a prostaglandin D2 receptor implicated in the recruitment of eosinophils and basophils within the asthmatic lung. Here we report the discovery of a novel series of 3-indolyl sultams that are low nM antagonists of CRTh2. These compounds proved to be selective over the other primary prostaglandin D2 receptor (DP1) as well as the thromboxane A2 receptor (TP).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
L. Nathan Tumey, Michael J. Robarge, Elizabeth Gleason, Jianping Song, Steven M. Murphy, George Ekema, Chris Doucette, Doug Hanniford, Marc Palmer, Gary Pawlowski, Joel Danzig, Margaret Loftus, Karen Hunady, Bruce Sherf, Robert W. Mays,