| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594741 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A new set of highly substituted pyridine derivatives has been synthesized by a product selective four component reaction of aryl aldehyde, malononitrile and 2-aryl/cyclohexylsulfanyl-1-aryl-1-ethanones in presence of sodium hydroxide in methyl/ethyl alcohol. Among the compounds, 4,6-bis(4-chlorophenyl)-5-[(4-chlorophenyl)sulfanyl]-2-methoxynicotinonitrile (4n) inhibited Mycobacterium tuberculosis (MTB) with minimum inhibitory concentration (MIC) of 3.1 μM and was more potent than ethambutol and pyrazinamide.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ramaiyan Manikannan, Shanmugam Muthusubramanian, Perumal Yogeeswari, Dharmarajan Sriram,