| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594745 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of pyrazolyl propionyl cyclohexenamides were discovered as full agonists for the high affinity niacin receptor GPR109A. The structure-activity relationship (SAR) studies were aimed to improve activity on GPR109A, reduce Cytochrome P450 2C8 (CYP2C8) and Cytochrome P450 2C9 (CYP2C9) inhibition, reduce serum shift and improve pharmacokinetic (PK) profiles.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fa-Xiang Ding, Hong C. Shen, Larrisa C. Wilsie, Mihajlo L. Krsmanovic, Andrew K. Taggart, Ning Ren, Tian-Quan Cai, Junying Wang, Xinchun Tong, Tom G. Holt, Qing Chen, M. Gerard Waters, Milton L. Hammond, James R. Tata, Steven L. Colletti,