| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594746 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The design, synthesis and pharmacological properties of a novel class of PPARα agonists is described. Compound 2 is a novel, potent and specific glycine amide with oral bioavailability in rodents. The compound is active in vivo and alters plasma lipids in hAPO-A1 transgenic mice after oral administration.
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Authors
Klaus Urbahns, Michael Woltering, Susanne Nikolic, Josef Pernerstorfer, Hilmar Bischoff, Elke Dittrich-Wengenroth, Klemens Lustig,