| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594759 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Carbamate derivatives of betulinic acid and betulin were synthesized and tested against fifteen tumor cell lines. The most active compounds 9 (bis(ethylcarbamate)betulin) and 11 (3-O-ethylcarbamate of 28-O-acetylbetulin) were found to be selectively cytotoxic towards tumor cell lines, inducing apoptosis by activation of caspase 3.
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Authors
Harish Kommera, Goran N. KaluÄeroviÄ, Sebastian Dittrich, Jutta Kalbitz, Birgit Dräger, Thomas Mueller, Reinhard Paschke,