| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594764 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A small set of boronic acids acting as low nanomolar inhibitors of AmpC β-lactamase were designed and synthesized in the effort to improve affinity, pharmacokinetic properties, and to provide a valid lead compound. X-ray crystallography revealed the binary complex of the best inhibitor bound to the enzyme, highlighting possibilities for its further rational derivatization and chemical optimization.
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Authors
Donatella Tondi, Samuele Calò, Brian K. Shoichet, Maria Paola Costi,