| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594767 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
Novel C-aryl glucoside SGLT2 inhibitors containing pyridazine motif were designed and synthesized for biological evaluation. Among various analogs, methylthio-pyridazine 32l demonstrated the best in vitro inhibitory activity against hSGLT2 in this series to date (IC50Â =Â 13.4Â nM).
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Authors
Min Ju Kim, Junwon Lee, Suk Youn Kang, Sung-Han Lee, Eun-Jung Son, Myung Eun Jung, Suk Ho Lee, Kwang-Seop Song, MinWoo Lee, Ho-Kyun Han, Jeongmin Kim, Jinhwa Lee,