| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594769 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose tolerance, and liver toxicity. An anthranilic acid was identified as an agonist of the niacin receptor. In order to improve efficacy and provide structural diversity, replacements for the anthranilic acid were investigated and several compounds with improved properties were identified.
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Authors
Darby Schmidt, Abigail Smenton, Subharekha Raghavan, Hong Shen, Fa-Xiang Ding, Ester Carballo-Jane, Silvi Luell, Tanya Ciecko, Tom G. Holt, Michael Wolff, Andrew Taggart, Larissa Wilsie, Mihajlo Krsmanovic, Ning Ren, Daniel Blom, Kang Cheng,