Article ID Journal Published Year Pages File Type
10594788 Bioorganic & Medicinal Chemistry Letters 2014 5 Pages PDF
Abstract
A series of diamino spirocyclic aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR, PK, and efficacy data are presented.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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