Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594788 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of diamino spirocyclic aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR, PK, and efficacy data are presented.
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Authors
John M. Keith, William M. Jones, Joan M. Pierce, Mark Seierstad, James A. Palmer, Michael Webb, Mark J. Karbarz, Brian P. Scott, Sandy J. Wilson, Lin Luo, Michelle L. Wennerholm, Leon Chang, Sean M. Brown, Michele Rizzolio, Raymond Rynberg,