| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594848 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein with aminoheterocycles appended onto the N-terminus of the chemotype were explored as urea mimetics. Potent compounds were discovered and were further optimized to improve metabolic stability and PXR transactivation profile.
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Authors
Yufeng Wang, Wu Yang, Heather J. Finlay, Lalgudi S. Harikrishnan, Ji Jiang, Muthoni G. Kamau, Katy Van Kirk, David S. Nirschl, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Paul G. Sleph, Richard Z. Yang, Christine S. Huang, Leonard P. Adam,