Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594878 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Novel iminothiazinylbutadienols and divinylpyrimidinethiones were designed and synthesized as analogues of curcumin with its diketone moiety masked as a heterocyclic adduct with thiourea. The chemical stability of these novel heterocyclic compounds was improved as compared to curcumin. They exhibit longer half-lives and do not react with nucleophilic thiols under physiological conditions. In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin Chen, Sadagopan Magesh, Hong Wang, Chung S. Yang, Ah-Ng Tony Kong, Longqin Hu,