| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594889 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A sulfonamide replacement of the P2-P3 amide bond in the context of macrocyclic HCV NS3 protease inhibitors was investigated. These analogs displayed good inhibitory potency in the absence of any P3 capping group. The synthesis and preliminary SAR are described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thorsten A. Kirschberg, Neil H. Squires, Huiling Yang, Amoreena C. Corsa, Yang Tian, Neeraj Tirunagari, X. Christopher Sheng, Choung U. Kim,