| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594898 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A novel series of hedgehog signaling pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
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Authors
Minhang Xin, Jun Wen, Feng Tang, Chongxing Tu, Wei Huang, Han Shen, Xinge Zhao, Lingfei Cheng, Mengyu Wang, Liandi Zhang,