| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594899 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
The synthesis and evaluation of analogs with extensive modifications of the 1,4-diamine core along with the structure activity relationships with respect to anti-HIV activity, CYP3A inhibitory activity, selectivity against other CYP enzymes and activation of the human pregnane X receptor (PXR) will be discussed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongtao Liu, Lianhong Xu, Hon Hui, Randy Vivian, Christian Callebaut, Bernard P. Murray, Allen Hong, Melody S. Lee, Luong K. Tsai, Jennifer K. Chau, Kirsten M. Stray, Carina Cannizzaro, You-Chul Choi, Gerry R. Rhodes, Manoj C. Desai,